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Jagannadha Rao, V.
- Validated Visible Spectrophotometric Methods Development for the Assay of Ropinirole Hydrochloride in Pharmaceutical Preparations
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Authors
Affiliations
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided& Autonomous), Vizianagaram-535002 (AP), IN
4 Department of Organic Chemistry& Analysis of Foods, Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam- 530003 Andhra Pradesh, IN
1 Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam -530003 Andhra Pradesh, IN
2 Department of Chemistry, Anil Neerukonda Institute of Technology and Sciences, Sangivalasa (AP), IN
3 Department of Chemistry, Maharajah’s College (Aided& Autonomous), Vizianagaram-535002 (AP), IN
4 Department of Organic Chemistry& Analysis of Foods, Drugs & Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam- 530003 Andhra Pradesh, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 5 (2012), Pagination: 267-271Abstract
Two simple and sensitive visible spectrophotometric methods (M1 and M2) have been developed for the estimation of ropinirole hydrochloride (RPR) in bulk and pharmaceutical dosage forms. Method M1 involves Internal salt formation of aconitic anhydride, dehydration product of citric acid [CIA] with acetic anhydride [Ac2O] to form colored chromogen with an absorption maximum of 580 nm and the method M2 is based on the formation of green colored coordination complex by the drug with cobalt thiocyanate which is quantitatively extractable into nitro benzene with an absorption maximum of 625 nm. Beer's law obeyed in the concentration range of 8-24μg/ml for method M1 and 16-48 μg/ml for method M2. Commercially available tablets were analyzed and the results are statistically compared with those obtained by the reference method and validated by recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of the ropinirole hydrochloride in the presence of other ingredients that are usually present in dosage forms. These methods offer the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.Keywords
Assay, Acetic Anhydride, Citric Acid, Cobalt Thiocyanate, Beer’s Law, Tablets.- A Computer Analysis of Long Time Deflection of Concrete Beams
Abstract Views :293 |
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Authors
Affiliations
1 Department of Civil Engineering, Andhra University College of Engineering, Visakhapatnam-3, IN
1 Department of Civil Engineering, Andhra University College of Engineering, Visakhapatnam-3, IN
Source
Journal of the Association of Engineers, India, Vol 52, No 1 (1977), Pagination: S7-S7Abstract
The use of high strength materials, ultimate strength design methods, longer spans and higher service stresses lead to slender structural beams, but associated with excessive deflections. These deflections further increase with time due to creep and shrinkage and cause serviceability failures.- A Computer Analysis of Long Time Deflection of Concrete Beams
Abstract Views :272 |
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Authors
Affiliations
1 Department of Civil Engineering, Andhra University College of Engineering, Visakhapatnam-3, IN
1 Department of Civil Engineering, Andhra University College of Engineering, Visakhapatnam-3, IN